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Reviewed November 2013
What is the official name of the RUNX1T1 gene?
The official name of this gene is “runt-related transcription factor 1; translocated to, 1 (cyclin D-related).”
RUNX1T1 is the gene's official symbol. The RUNX1T1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the RUNX1T1 gene?
The RUNX1T1 gene provides instructions for making a protein commonly referred to as ETO, which helps regulate the activity of genes. ETO is considered a transcriptional corepressor because it turns off (represses) gene activity. It performs this function by attaching (binding) to proteins that normally turn genes on and blocking their activity. It also interacts with other corepressors to help keep genes turned off.
Does the RUNX1T1 gene share characteristics with other genes?
The RUNX1T1 gene belongs to a family of genes called ZMYND (zinc fingers, MYND-type).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the RUNX1T1 gene related to health conditions?
Where is the RUNX1T1 gene located?
Cytogenetic Location: 8q22
Molecular Location on chromosome 8: base pairs 91,954,966 to 92,103,225
The RUNX1T1 gene is located on the long (q) arm of chromosome 8 at position 22.
More precisely, the RUNX1T1 gene is located from base pair 91,954,966 to base pair 92,103,225 on chromosome 8.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about RUNX1T1?
You and your healthcare professional may find the following resources about RUNX1T1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the RUNX1T1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding RUNX1T1?
acute ; acute myelogenous leukemia ; acute myeloid leukemia ; AML ; cancer ; cell ; chromosome ; corepressor ; differentiation ; DNA ; domain ; gene ; leukemia ; myelogenous ; myeloid ; protein ; rearrangement ; subunit ; transcription ; transcription factor ; translocation ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.