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Reviewed January 2008
What is the official name of the RPS6KA3 gene?
The official name of this gene is “ribosomal protein S6 kinase, 90kDa, polypeptide 3.”
RPS6KA3 is the gene's official symbol. The RPS6KA3 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the RPS6KA3 gene?
The RPS6KA3 gene provides instructions for making a protein that is part of a family called ribosomal S6 kinases (RSKs). These proteins help regulate the activity of certain genes and are involved in signaling within cells. RSK proteins are thought to play a role in several important cellular processes including cell growth and division (proliferation), cell specialization (differentiation), and the self-destruction of cells (apoptosis).
Proteins in the RSK family, including the RPS6KA3 protein, are also included in a larger family called ribosomal proteins (RPS). These proteins are components of cellular structures called ribosomes, which process the cell's genetic instructions to create new proteins. RSK proteins are among the ribosomal proteins that also have functions unrelated to protein production.
The protein made by the RPS6KA3 gene appears to play an important role in the brain. The protein is involved in cell signaling pathways that are required for learning, the formation of long-term memories, and the survival of nerve cells.
How are changes in the RPS6KA3 gene related to health conditions?
Where is the RPS6KA3 gene located?
Cytogenetic Location: Xp22.2-p22.1
Molecular Location on the X chromosome: base pairs 20,149,911 to 20,267,095
The RPS6KA3 gene is located on the short (p) arm of the X chromosome between positions 22.2 and 22.1.
More precisely, the RPS6KA3 gene is located from base pair 20,149,911 to base pair 20,267,095 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about RPS6KA3?
You and your healthcare professional may find the following resources about RPS6KA3 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the RPS6KA3 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding RPS6KA3?
acids ; apoptosis ; cell ; chromosome ; differentiation ; disability ; gene ; insulin ; kinase ; mental retardation ; proliferation ; protein ; ribosomes ; serine ; syndrome ; threonine ; threonine kinase
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.