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Reviewed February 2012
What is the official name of the RPL5 gene?
The official name of this gene is “ribosomal protein L5.”
RPL5 is the gene's official symbol. The RPL5 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the RPL5 gene?
The RPL5 gene provides instructions for making one of approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. Ribosomes process the cell's genetic instructions to create proteins.
Each ribosome is made up of two parts (subunits) called the large and small subunits. The protein produced from the RPL5 gene is among those found in the large subunit.
The specific functions of the RPL5 protein and the other ribosomal proteins within these subunits are unclear. Some ribosomal proteins are involved in the assembly or stability of ribosomes. Others help carry out the ribosome's main function of building new proteins. Studies suggest that some ribosomal proteins may have other functions, such as participating in chemical signaling pathways within the cell, regulating cell division, and controlling the self-destruction of cells (apoptosis).
Does the RPL5 gene share characteristics with other genes?
The RPL5 gene belongs to a family of genes called RPL (L ribosomal proteins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the RPL5 gene related to health conditions?
Where is the RPL5 gene located?
Cytogenetic Location: 1p22.1
Molecular Location on chromosome 1: base pairs 92,832,037 to 92,841,924
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The RPL5 gene is located on the short (p) arm of chromosome 1 at position 22.1.
More precisely, the RPL5 gene is located from base pair 92,832,037 to base pair 92,841,924 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about RPL5?
You and your healthcare professional may find the following resources about RPL5 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the RPL5 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding RPL5?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.