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Reviewed September 2015
What is the official name of the ROR2 gene?
The official name of this gene is “receptor tyrosine kinase-like orphan receptor 2.”
ROR2 is the gene's official symbol. The ROR2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ROR2 gene?
The ROR2 gene provides instructions for making a protein whose function is not well understood. The ROR2 protein is part of a family of proteins known as receptor tyrosine kinases (RTKs), which play a role in chemical signaling within cells. RTKs are involved in many cell functions, including cell growth and division (proliferation), the process by which cells mature to carry out specific functions (differentiation), cell survival, and cell movement (motility).
Researchers believe that the ROR2 protein plays an essential role in development starting before birth. It is involved in chemical signaling pathways called WNT signaling, which affect many aspects of development. These pathways control the activity of genes needed at specific times, and they regulate the interactions between cells as organs and tissues are forming. In particular, the ROR2 protein appears to be critical for the normal formation of the skeleton, heart, and genitals.
Does the ROR2 gene share characteristics with other genes?
The ROR2 gene belongs to a family of genes called immunoglobulin superfamily, I-set domain containing (immunoglobulin superfamily, I-set domain containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ROR2 gene related to health conditions?
Where is the ROR2 gene located?
Cytogenetic Location: 9q22
Molecular Location on chromosome 9: base pairs 91,722,596 to 91,950,162
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The ROR2 gene is located on the long (q) arm of chromosome 9 at position 22.
More precisely, the ROR2 gene is located from base pair 91,722,596 to base pair 91,950,162 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ROR2?
You and your healthcare professional may find the following resources about ROR2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ROR2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ROR2?
acids ; autosomal ; autosomal dominant ; autosomal recessive ; brachydactyly ; cell ; differentiation ; gene ; genitals ; inheritance ; kinase ; pattern of inheritance ; proliferation ; protein ; receptor ; recessive ; syndrome ; tyrosine
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.