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Reviewed July 2010
What is the official name of the RNASEH2B gene?
The official name of this gene is “ribonuclease H2, subunit B.”
RNASEH2B is the gene's official symbol. The RNASEH2B gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the RNASEH2B gene?
The RNASEH2B gene provides instructions for making one part (subunit) of a group of proteins called the RNase H2 complex. This complex is a ribonuclease, which means it is an enzyme that helps break down RNA, a chemical cousin of DNA. In particular, the RNase H2 complex helps break down molecules in which one strand of RNA is combined with one strand of DNA (RNA-DNA hybrids). These hybrids are formed during DNA copying (replication) and are found in all cells.
The RNase H2 complex is involved in DNA replication, error repair, and other cellular functions. Researchers believe that these additional functions may include helping to prevent inappropriate immune system activation.
How are changes in the RNASEH2B gene related to health conditions?
Where is the RNASEH2B gene located?
Cytogenetic Location: 13q14.3
Molecular Location on chromosome 13: base pairs 50,909,677 to 50,970,459
The RNASEH2B gene is located on the long (q) arm of chromosome 13 at position 14.3.
More precisely, the RNASEH2B gene is located from base pair 50,909,677 to base pair 50,970,459 on chromosome 13.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about RNASEH2B?
You and your healthcare professional may find the following resources about RNASEH2B helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the RNASEH2B gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding RNASEH2B?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.