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Reviewed May 2013
What is the official name of the REN gene?
The official name of this gene is “renin.”
REN is the gene's official symbol. The REN gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the REN gene?
The REN gene provides instructions for making a protein called renin, which is produced in the kidneys. This protein is part of the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body. In the first step of this process, renin converts a protein called angiotensinogen into angiotensin I. Through an additional step, angiotensin I is converted to angiotensin II. Angiotensin II causes blood vessels to narrow (constrict), which results in increased blood pressure. Angiotensin II also stimulates production of the hormone aldosterone, which triggers the absorption of water and salt by the kidneys. The increased amount of fluid in the body also increases blood pressure. Proper blood pressure during fetal growth, which delivers oxygen to the developing tissues, is required for normal development of the kidneys, particularly of structures called the proximal tubules, and other tissues. In addition, angiotensin II may play a more direct role in kidney development, perhaps by affecting growth factors involved in development of kidney structures.
How are changes in the REN gene related to health conditions?
Where is the REN gene located?
Cytogenetic Location: 1q32
Molecular Location on chromosome 1: base pairs 204,154,816 to 204,166,337
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The REN gene is located on the long (q) arm of chromosome 1 at position 32.
More precisely, the REN gene is located from base pair 204,154,816 to base pair 204,166,337 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about REN?
You and your healthcare professional may find the following resources about REN helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the REN gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding REN?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.