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Reviewed August 2013
What is the official name of the RELN gene?
The official name of this gene is “reelin.”
RELN is the gene's official symbol. The RELN gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the RELN gene?
The RELN gene provides instructions for making a protein called reelin. This protein is produced in the brain both before and after birth. Reelin is released by certain brain cells; then it attaches (binds) to specific receptor proteins. In the developing brain, this binding turns on (activates) a signaling pathway that triggers nerve cells (neurons) to migrate to their proper locations.
After birth, reelin likely plays a role in many brain processes, including the extension of axons and dendrites, which are specialized outgrowths from nerve cells that are essential for the transmission of nerve impulses. Reelin may also regulate synaptic plasticity, which is the ability of connections between neurons (synapses) to change and adapt over time in response to experience. Additionally, reelin controls the release of chemicals that relay signals in the nervous system (neurotransmitters).
How are changes in the RELN gene related to health conditions?
Where is the RELN gene located?
Cytogenetic Location: 7q22
Molecular Location on chromosome 7: base pairs 103,471,784 to 103,989,516
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The RELN gene is located on the long (q) arm of chromosome 7 at position 22.
More precisely, the RELN gene is located from base pair 103,471,784 to base pair 103,989,516 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about RELN?
You and your healthcare professional may find the following resources about RELN helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the RELN gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding RELN?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.