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The information on this page was automatically extracted from online scientific databases.

What is the official name of the RASGRP1 gene?

The official name of this gene is “RAS guanyl releasing protein 1 (calcium and DAG-regulated).”

RASGRP1 is the gene's official symbol. The RASGRP1 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the RASGRP1 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

From UniProt (GRP1_HUMAN)This link leads to a site outside Genetics Home Reference.:

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332).

How are changes in the RASGRP1 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the RASGRP1 gene.
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the RASGRP1 gene and its association with health conditions.

Where is the RASGRP1 gene located?

Cytogenetic Location: 15q14

Molecular Location on chromosome 15: base pairs 38,488,101 to 38,564,806

The RASGRP1 gene is located on the long (q) arm of chromosome 15 at position 14.

The RASGRP1 gene is located on the long (q) arm of chromosome 15 at position 14.

More precisely, the RASGRP1 gene is located from base pair 38,488,101 to base pair 38,564,806 on chromosome 15.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about RASGRP1?

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the RASGRP1 gene or gene products?

  • hRasGRP1
  • V

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding RASGRP1?

autoimmune ; autoimmunity ; B-cells ; bone marrow ; calcium ; cell ; chronic ; connective tissue ; cytokine ; differentiation ; domain ; erythrocyte ; etiology ; gene ; GTP ; guanine ; homeostasis ; isoforms ; kinase ; lymphocyte ; nucleotide ; protein ; secretion ; susceptibility ; T-cells ; tissue ; T-lymphocyte ; transcript

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: November 23, 2015