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Reviewed April 2011
What is the official name of the RAF1 gene?
The official name of this gene is “Raf-1 proto-oncogene, serine/threonine kinase.”
RAF1 is the gene's official symbol. The RAF1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the RAF1 gene?
The RAF1 gene provides instructions for making a protein that is part of a signaling pathway called the RAS/MAPK pathway, which transmits chemical signals from outside the cell to the cell's nucleus. RAS/MAPK signaling helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis).
The RAF1 gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous.
How are changes in the RAF1 gene related to health conditions?
Where is the RAF1 gene located?
Cytogenetic Location: 3p25
Molecular Location on chromosome 3: base pairs 12,583,601 to 12,664,201
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The RAF1 gene is located on the short (p) arm of chromosome 3 at position 25.
More precisely, the RAF1 gene is located from base pair 12,583,601 to base pair 12,664,201 on chromosome 3.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about RAF1?
You and your healthcare professional may find the following resources about RAF1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the RAF1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding RAF1?
acids ; amino acid ; apoptosis ; cancer ; cardiac ; cardiomyopathy ; cell ; cell division ; class ; colorectal ; differentiation ; gene ; hypertrophic ; incidence ; inherited ; kinase ; leucine ; mutation ; nucleus ; oncogene ; ovarian ; proliferation ; protein ; proto-oncogene ; RAS ; serine ; short stature ; stature ; syndrome ; threonine ; threonine kinase ; valine
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (9 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.