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Reviewed September 2013
What is the official name of the RAB27A gene?
The official name of this gene is “RAB27A, member RAS oncogene family.”
RAB27A is the gene's official symbol. The RAB27A gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the RAB27A gene?
The RAB27A gene provides instructions for making a protein that is involved in a process called vesicle trafficking, which moves proteins and other molecules within cells in sac-like structures called vesicles. Although the Rab27a protein is found in cells and tissues throughout the body, it appears to be most critical in pigment-producing cells called melanocytes and in certain immune system cells.
In melanocytes, the Rab27a protein helps transport structures called melanosomes. These structures produce a pigment called melanin, which is the substance that gives skin, hair, and eyes their color (pigmentation). Rab27a interacts with proteins produced from the MLPH and MYO5A genes to form a complex that transports melanosomes to the outer edges of melanocytes. From there, the melanosomes are transferred to other types of cells, where they provide the pigment needed for normal hair, skin, and eye coloring.
The Rab27a protein also plays an important role in immune system cells called T-lymphocytes. These cells recognize and attack foreign invaders, such as viruses and bacteria, to prevent infection and illness. Specifically, Rab27a is involved in cytotoxic granule exostosis, which is the process by which T-lymphocytes release cell-killing (cytotoxic) compounds to destroy foreign invaders.
Does the RAB27A gene share characteristics with other genes?
The RAB27A gene belongs to a family of genes called RAB (RAB, member RAS oncogene family).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the RAB27A gene related to health conditions?
Where is the RAB27A gene located?
Cytogenetic Location: 15q21.3
Molecular Location on chromosome 15: base pairs 55,202,966 to 55,289,828
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The RAB27A gene is located on the long (q) arm of chromosome 15 at position 21.3.
More precisely, the RAB27A gene is located from base pair 55,202,966 to base pair 55,289,828 on chromosome 15.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about RAB27A?
You and your healthcare professional may find the following resources about RAB27A helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the RAB27A gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding RAB27A?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.