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Reviewed May 2013
What is the official name of the RAB23 gene?
The official name of this gene is “RAB23, member RAS oncogene family.”
RAB23 is the gene's official symbol. The RAB23 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the RAB23 gene?
The RAB23 gene provides instructions for making a protein that is involved in a process called vesicle trafficking, which moves proteins and other molecules within cells in sac-like structures called vesicles. A vesicle forms when the cell membrane folds around a substance outside the cell (such as a protein). The vesicle is drawn into the cell, pinched off from the cell membrane (a process called endocytosis), and attached to the Rab23 protein. Once inside the cell, the vesicle is guided by the Rab23 protein to its proper destination. Vesicle trafficking is important for the transport of materials that are needed to trigger signaling during development.
Through the transport of certain proteins, the Rab23 protein regulates a specific developmental pathway called the hedgehog signaling pathway that is critical in cell growth (proliferation), cell specialization, and the normal shaping (patterning) of many parts of the body during embryonic development.
Does the RAB23 gene share characteristics with other genes?
The RAB23 gene belongs to a family of genes called RAB (RAB, member RAS oncogene family).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the RAB23 gene related to health conditions?
Where is the RAB23 gene located?
Cytogenetic Location: 6p11
Molecular Location on chromosome 6: base pairs 57,186,992 to 57,222,314
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The RAB23 gene is located on the short (p) arm of chromosome 6 at position 11.
More precisely, the RAB23 gene is located from base pair 57,186,992 to base pair 57,222,314 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about RAB23?
You and your healthcare professional may find the following resources about RAB23 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the RAB23 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding RAB23?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)