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References
These sources were used to develop the Genetics Home Reference
gene summary
on the
PTEN
gene.
Baker SJ. PTEN enters the nuclear age. Cell. 2007 Jan 12;128(1):25-8. Review.
PubMed citation
Butler MG, Dasouki MJ, Zhou XP, Talebizadeh Z, Brown M, Takahashi TN, Miles JH, Wang CH, Stratton R, Pilarski R, Eng C. Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations. J Med Genet. 2005 Apr;42(4):318-21.
PubMed citation
Chow LM, Baker SJ. PTEN function in normal and neoplastic growth. Cancer Lett. 2006 Sep 28;241(2):184-96. Epub 2006 Jan 18. Review.
PubMed citation
Chu EC, Tarnawski AS. PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit. 2004 Oct;10(10):RA235-41. Epub 2004 Sep 23. Review.
PubMed citation
Eng C. PTEN: one gene, many syndromes. Hum Mutat. 2003 Sep;22(3):183-98. Review.
PubMed citation
Entrez
Gene
Gene Review: PTEN Hamartoma Tumor Syndrome
(PHTS)
Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev. 2005 Sep 1;19(17):2054-65. Epub 2005 Aug 17.
PubMed citation
Herman GE, Butter E, Enrile B, Pastore M, Prior TW, Sommer A. Increasing knowledge of PTEN germline mutations: Two additional patients with autism and macrocephaly. Am J Med Genet A. 2007 Mar 15;143(6):589-93.
PubMed citation
Leslie NR, Downes CP. PTEN function: how normal cells control it and tumour cells lose it. Biochem J. 2004 Aug 15;382(Pt 1):1-11. Review.
PubMed citation
Pilarski R, Eng C. Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome. J Med Genet. 2004 May;41(5):323-6. Review.
PubMed citation
Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol. 2004 Jul 15;22(14):2954-63. Review.
PubMed citation
Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell. 2007 Jan 12;128(1):157-70.
PubMed citation
Waite KA, Eng C. Protean PTEN: form and function. Am J Hum Genet. 2002 Apr;70(4):829-44. Epub 2002 Mar 1. Review.
PubMed citation
Zhou XP, Waite KA, Pilarski R, Hampel H, Fernandez MJ, Bos C, Dasouki M, Feldman GL, Greenberg LA, Ivanovich J, Matloff E, Patterson A, Pierpont ME, Russo D, Nassif NT, Eng C. Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway. Am J Hum Genet. 2003 Aug;73(2):404-11. Epub 2003 Jul 3.
PubMed citation
Reviewed: August 2007
Published: May 21, 2012
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