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Reviewed November 2013
What is the official name of the PSMB8 gene?
The official name of this gene is “proteasome subunit beta 8.”
PSMB8 is the gene's official symbol. The PSMB8 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PSMB8 gene?
The PSMB8 gene provides instructions for making one part (subunit) of cell structures called immunoproteasomes. Immunoproteasomes are specialized versions of proteasomes, which are large complexes that recognize and break down (degrade) unneeded, excess, or abnormal proteins within cells. This activity is necessary for many essential cell functions. While proteasomes are found in many types of cells, immunoproteasomes are located primarily in immune system cells. These structures play an important role in regulating the immune system's response to foreign invaders, such as viruses and bacteria. One of the primary functions of immunoproteasomes is to help the immune system distinguish the body's own proteins from proteins made by foreign invaders, so the immune system can respond appropriately to infection.
Immunoproteasomes may also have other functions in immune system cells and possibly in other types of cells. They appear to be involved in some of the same fundamental cell activities as regular proteasomes, such as regulating the amount of various proteins in cells (protein homeostasis), cell growth and division, the process by which cells mature to carry out specific functions (differentiation), chemical signaling within cells, and the activity of genes. Studies suggest that, through unknown mechanisms, the subunit produced from the PSMB8 gene in particular may be involved in the maturation of fat cells (adipocytes).
Does the PSMB8 gene share characteristics with other genes?
The PSMB8 gene belongs to a family of genes called PSM (proteasome (prosome, macropain) subunits).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the PSMB8 gene related to health conditions?
Where is the PSMB8 gene located?
Cytogenetic Location: 6p21.3
Molecular Location on chromosome 6: base pairs 32,840,717 to 32,844,935
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The PSMB8 gene is located on the short (p) arm of chromosome 6 at position 21.3.
More precisely, the PSMB8 gene is located from base pair 32,840,717 to base pair 32,844,935 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PSMB8?
You and your healthcare professional may find the following resources about PSMB8 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PSMB8 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PSMB8?
adipocytes ; amino acid ; anemia ; atrophy ; atypical ; bacteria ; catalytic ; cell ; chronic ; class ; cysteine ; degrade ; differentiation ; erythema ; fat cells ; fatty tissue ; gene ; glycine ; hepatosplenomegaly ; homeostasis ; immune system ; infection ; inflammation ; joint ; lipodystrophy ; methionine ; MHC ; microcytic anemia ; mutation ; panniculitis ; population ; protease ; proteasome ; protein ; subunit ; syndrome ; threonine ; tissue ; ubiquitin ; valine ; wasting
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.