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Reviewed August 2010
What is the official name of the PROP1 gene?
The official name of this gene is “PROP paired-like homeobox 1.”
PROP1 is the gene's official symbol. The PROP1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PROP1 gene?
The PROP1 gene provides instructions for making a protein that helps control the activity of many other genes. On the basis of this action, the PROP1 protein is known as a transcription factor. This protein is found only in the pituitary gland, which is located at the base of the brain. The pituitary gland releases hormones needed for growth, reproduction, and other critical body functions. The PROP1 protein helps in the specialization (differentiation) of cell types within the pituitary gland.
Does the PROP1 gene share characteristics with other genes?
The PROP1 gene belongs to a family of genes called homeobox (homeoboxes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the PROP1 gene related to health conditions?
Where is the PROP1 gene located?
Cytogenetic Location: 5q35.3
Molecular Location on chromosome 5: base pairs 177,992,235 to 177,996,242
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The PROP1 gene is located on the long (q) arm of chromosome 5 at position 35.3.
More precisely, the PROP1 gene is located from base pair 177,992,235 to base pair 177,996,242 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PROP1?
You and your healthcare professional may find the following resources about PROP1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PROP1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PROP1?
cell ; deficiency ; deletion ; differentiation ; DNA ; gene ; homeobox ; homeodomain ; hormone ; mutation ; pituitary gland ; protein ; puberty ; reproduction ; short stature ; stature ; transcription ; transcription factor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.