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The official name of this gene is “protein kinase, AMP-activated, beta 2 non-catalytic subunit.”
PRKAB2 is the gene's official symbol. The PRKAB2 gene is also known by other names, listed below.
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
|602741 (http://omim.org/entry/602741)||PROTEIN KINASE, AMP-ACTIVATED, NONCATALYTIC, BETA-2|
Cytogenetic Location: 1q21.1
Molecular Location on chromosome 1: base pairs 147,155,105 to 147,172,588
The PRKAB2 gene is located on the long (q) arm of chromosome 1 at position 21.1.
More precisely, the PRKAB2 gene is located from base pair 147,155,105 to base pair 147,172,588 on chromosome 1.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
actin ; ATP ; carbohydrate ; carboxylase ; catalytic ; cell ; cholesterol ; CoA ; cytoskeleton ; enzyme ; expressed ; gene ; intracellular ; kinase ; lipid ; lipid biosynthesis ; metabolism ; myosin ; phosphorylation ; proliferation ; protein ; skeletal muscle ; subunit ; tissue ; transcript ; transcription
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.