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The information on this page was automatically extracted from online scientific databases.

What is the official name of the PRDM1 gene?

The official name of this gene is “PR domain 1.”

PRDM1 is the gene's official symbol. The PRDM1 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the PRDM1 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]

From UniProt (PRDM1_HUMAN)This link leads to a site outside Genetics Home Reference.:

Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569).

How are changes in the PRDM1 gene related to health conditions?

Genetics Home Reference provides information about rheumatoid arthritis, which is associated with changes in the PRDM1 gene.
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the PRDM1 gene and its association with health conditions.

Where is the PRDM1 gene located?

Cytogenetic Location: 6q21

Molecular Location on chromosome 6: base pairs 106,086,320 to 106,109,939

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBIThis link leads to a site outside Genetics Home Reference.)

The PRDM1 gene is located on the long (q) arm of chromosome 6 at position 21.

The PRDM1 gene is located on the long (q) arm of chromosome 6 at position 21.

More precisely, the PRDM1 gene is located from base pair 106,086,320 to base pair 106,109,939 on chromosome 6.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about PRDM1?

You and your healthcare professional may find the following resources about PRDM1 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the PRDM1 gene or gene products?

  • BLIMP1
  • PRDI-BF1

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding PRDM1?

B-lymphocytes ; domain ; gene ; gene expression ; IFN ; isoforms ; promoter ; protein ; repressor ; transcript ; transcription ; virus

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Published: February 8, 2016