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Reviewed February 2016
What is the official name of the POU3F4 gene?
The official name of this gene is “POU class 3 homeobox 4.”
POU3F4 is the gene's official symbol. The POU3F4 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the POU3F4 gene?
The POU3F4 gene provides instructions for making a protein that helps regulate the activity of other genes. Based on this role, the protein is called a transcription factor. The POU3F4 gene is part of a larger family of transcription factor genes called POU domain genes. These genes play a role in determining cell types in the brain and spinal cord (the central nervous system) during early development. The proteins produced from genes in the POU domain family each include two regions, called the POU-specific domain and POU homeodomain, that bind to the DNA of other genes.
The POU3F4 protein is likely to be involved in the development of the middle and inner ear, and it is also active in certain regions of the brain before birth. Researchers are working to determine which genes are regulated by this protein.
Does the POU3F4 gene share characteristics with other genes?
The POU3F4 gene belongs to a family of genes called homeobox (homeoboxes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the POU3F4 gene related to health conditions?
Where is the POU3F4 gene located?
Cytogenetic Location: Xq21.1
Molecular Location on the X chromosome: base pairs 83,508,261 to 83,509,767
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The POU3F4 gene is located on the long (q) arm of the X chromosome at position 21.1.
More precisely, the POU3F4 gene is located from base pair 83,508,261 to base pair 83,509,767 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about POU3F4?
You and your healthcare professional may find the following resources about POU3F4 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the POU3F4 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding POU3F4?
acids ; cell ; central nervous system ; chromosome ; class ; complication ; DNA ; domain ; gene ; homeobox ; homeodomain ; nervous system ; postlingual ; prelingual ; protein ; sex chromosomes ; sign ; stapes ; surgery ; transcription ; transcription factor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.