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Reviewed June 2013
What is the official name of the POLR3B gene?
The official name of this gene is “polymerase (RNA) III (DNA directed) polypeptide B.”
POLR3B is the gene's official symbol. The POLR3B gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the POLR3B gene?
The POLR3B gene provides instructions for making one part (subunit) of an enzyme called RNA polymerase III. This enzyme is involved in the production (synthesis) of ribonucleic acid (RNA), a chemical cousin of DNA. The RNA polymerase III enzyme attaches (binds) to DNA and synthesizes RNA in accordance with the instructions carried by the DNA, a process called transcription. RNA polymerase III helps synthesize several forms of RNA, including ribosomal RNA (rRNA) and transfer RNA (tRNA). Molecules of rRNA and tRNA assemble protein building blocks (amino acids) into working proteins; this process is essential for the normal functioning and survival of cells.
Does the POLR3B gene share characteristics with other genes?
The POLR3B gene belongs to a family of genes called POLR (RNA polymerase subunits).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the POLR3B gene related to health conditions?
Where is the POLR3B gene located?
Cytogenetic Location: 12q23.3
Molecular Location on chromosome 12: base pairs 106,357,658 to 106,510,198
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The POLR3B gene is located on the long (q) arm of chromosome 12 at position 23.3.
More precisely, the POLR3B gene is located from base pair 106,357,658 to base pair 106,510,198 on chromosome 12.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about POLR3B?
You and your healthcare professional may find the following resources about POLR3B helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the POLR3B gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding POLR3B?
acids ; ataxia ; atrophy ; corpus callosum ; disability ; DNA ; DNA-directed RNA polymerase ; enzyme ; gene ; hypodontia ; hypogonadism ; hypogonadotropic ; hypoplasia ; leukodystrophy ; molecule ; nervous system ; oligodontia ; protein ; ribonucleic acid ; ribosomal RNA ; RNA ; RNA polymerase ; subunit ; syndrome ; synthesis ; transcription ; transfer RNA ; tremor ; tRNA ; white matter
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.