|A service of the U.S. National Library of Medicine®|
On this page:
Reviewed June 2013
What is the official name of the POLR3A gene?
The official name of this gene is “polymerase (RNA) III (DNA directed) polypeptide A, 155kDa.”
POLR3A is the gene's official symbol. The POLR3A gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the POLR3A gene?
The POLR3A gene provides instructions for making the largest part (subunit) of an enzyme called RNA polymerase III. This enzyme is involved in the production (synthesis) of ribonucleic acid (RNA), a chemical cousin of DNA. The RNA polymerase III enzyme attaches (binds) to DNA and synthesizes RNA in accordance with the instructions carried by the DNA, a process called transcription. RNA polymerase III helps synthesize several forms of RNA, including ribosomal RNA (rRNA) and transfer RNA (tRNA). Molecules of rRNA and tRNA assemble protein building blocks (amino acids) into working proteins; this process is essential for the normal functioning and survival of cells.
Does the POLR3A gene share characteristics with other genes?
The POLR3A gene belongs to a family of genes called POLR (RNA polymerase subunits).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the POLR3A gene related to health conditions?
Where is the POLR3A gene located?
Cytogenetic Location: 10q22.3
Molecular Location on chromosome 10: base pairs 77,975,149 to 78,029,540
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The POLR3A gene is located on the long (q) arm of chromosome 10 at position 22.3.
More precisely, the POLR3A gene is located from base pair 77,975,149 to base pair 78,029,540 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about POLR3A?
You and your healthcare professional may find the following resources about POLR3A helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the POLR3A gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding POLR3A?
acids ; ataxia ; atrophy ; corpus callosum ; disability ; DNA ; DNA-directed RNA polymerase ; enzyme ; gene ; hypodontia ; hypogonadism ; hypogonadotropic ; hypoplasia ; leukodystrophy ; molecule ; nervous system ; oligodontia ; protein ; ribonucleic acid ; ribosomal RNA ; RNA ; RNA polymerase ; subunit ; syndrome ; synthesis ; transcription ; transfer RNA ; tremor ; tRNA ; white matter
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.