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Reviewed April 2011
What is the official name of the PML gene?
The official name of this gene is “promyelocytic leukemia.”
PML is the gene's official symbol. The PML gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PML gene?
The PML gene provides instructions for a protein that acts as a tumor suppressor, which means it prevents cells from growing and dividing too rapidly or in an uncontrolled way. The PML protein is found in distinct structures in the nucleus of a cell called PML nuclear bodies (PML-NBs). In the PML-NBs, the PML protein interacts with other proteins that are involved in cell growth and division (proliferation) and self-destruction (apoptosis). The PML protein is able to block cell proliferation and induce apoptosis in combination with other proteins. Researchers believe that the structure of the PML-NBs is required for blocking proliferation and inducing apoptosis.
Does the PML gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the PML gene related to health conditions?
Where is the PML gene located?
Cytogenetic Location: 15q22
Molecular Location on chromosome 15: base pairs 73,994,672 to 74,047,818
The PML gene is located on the long (q) arm of chromosome 15 at position 22.
More precisely, the PML gene is located from base pair 73,994,672 to base pair 74,047,818 on chromosome 15.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PML?
You and your healthcare professional may find the following resources about PML helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PML gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PML?
acute ; apoptosis ; biomarker ; bone marrow ; cancer ; cell ; cell proliferation ; chromosome ; differentiation ; gene ; gene transcription ; inherited ; leukemia ; localize ; motif ; mutation ; nucleus ; pharmacogenetics ; proliferation ; protein ; rearrangement ; somatic mutation ; stage ; tissue ; transcription ; translocation ; tumor ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.