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Reviewed August 2012
What is the official name of the PLG gene?
The official name of this gene is “plasminogen.”
PLG is the gene's official symbol. The PLG gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PLG gene?
The PLG gene provides instructions for making a protein called plasminogen, which is produced in the liver. Enzymes called plasminogen activators convert plasminogen into the protein plasmin, which breaks down another protein called fibrin. Fibrin is the main protein involved in blood clots and is important for wound healing, creating the framework for normal tissue to grow back. Excess fibrin is broken down when no longer needed, and the new, more flexible normal tissue takes its place.
How are changes in the PLG gene related to health conditions?
Where is the PLG gene located?
Cytogenetic Location: 6q26
Molecular Location on chromosome 6: base pairs 160,702,193 to 160,754,054
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The PLG gene is located on the long (q) arm of chromosome 6 at position 26.
More precisely, the PLG gene is located from base pair 160,702,193 to base pair 160,754,054 on chromosome 6.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PLG?
You and your healthcare professional may find the following resources about PLG helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PLG gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PLG?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.