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Reviewed September 2012
What is the official name of the PLA2G6 gene?
The official name of this gene is “phospholipase A2, group VI (cytosolic, calcium-independent).”
PLA2G6 is the gene's official symbol. The PLA2G6 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PLA2G6 gene?
The PLA2G6 gene provides instructions for making a type of enzyme called an A2 phospholipase. This type of enzyme is involved in breaking down (metabolizing) fats called phospholipids. Phospholipid metabolism is important for many body processes, including helping to maintain the integrity of the cell membrane. Specifically, the A2 phospholipase produced from the PLA2G6 gene, sometimes called PLA2 group VI, helps to regulate the levels of a compound called phosphatidylcholine, which is abundant in the cell membrane.
Does the PLA2G6 gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the PLA2G6 gene related to health conditions?
Where is the PLA2G6 gene located?
Cytogenetic Location: 22q13.1
Molecular Location on chromosome 22: base pairs 38,111,494 to 38,192,108
The PLA2G6 gene is located on the long (q) arm of chromosome 22 at position 13.1.
More precisely, the PLA2G6 gene is located from base pair 38,111,494 to base pair 38,192,108 on chromosome 22.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PLA2G6?
You and your healthcare professional may find the following resources about PLA2G6 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PLA2G6 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PLA2G6?
atypical ; axons ; bradykinesia ; calcium ; cell ; cell membrane ; compound ; disability ; domain ; dystonia ; enzyme ; gene ; involuntary ; iron ; kinase ; metabolism ; neurological ; parkinsonism ; phospholipid ; phospholipids ; spectrum ; teenage
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (12 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.