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Reviewed July 2014
What is the official name of the PIK3CD gene?
The official name of this gene is “phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta.”
PIK3CD is the gene's official symbol. The PIK3CD gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PIK3CD gene?
The PIK3CD gene provides instructions for making the p110 delta (p110δ) protein, which is one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). The version of PI3K containing the p110δ subunit, called PI3K-delta, is specifically found in white blood cells, including immune system cells (lymphocytes) called B cells and T cells. These cells recognize and attack foreign invaders, such as viruses and bacteria, to prevent infection.
Like other kinases, PI3K-delta adds a cluster of oxygen and phosphorus atoms (a phosphate group) to other proteins through a process called phosphorylation. PI3K-delta phosphorylates certain signaling molecules, which triggers a series of additional reactions that transmit chemical signals within cells. In lymphocytes, PI3K-delta signaling is important for many cell activities, including cell growth and division (proliferation) and maturation (differentiation). PI3K-delta helps direct B cells and T cells to differentiate into different types, each of which has a distinct function in the immune system.
How are changes in the PIK3CD gene related to health conditions?
Where is the PIK3CD gene located?
Cytogenetic Location: 1p36.2
Molecular Location on chromosome 1: base pairs 9,629,888 to 9,729,113
The PIK3CD gene is located on the short (p) arm of chromosome 1 at position 36.2.
More precisely, the PIK3CD gene is located from base pair 9,629,888 to base pair 9,729,113 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PIK3CD?
You and your healthcare professional may find the following resources about PIK3CD helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PIK3CD gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PIK3CD?
acids ; amino acid ; bacteria ; cancer ; catalytic ; cell ; chronic ; differentiation ; enzyme ; gene ; glutamic acid ; immune system ; immunodeficiency ; infection ; kinase ; lymph ; lymphoma ; lysine ; mutation ; oxygen ; phosphate ; phosphorus ; phosphorylation ; proliferation ; protein ; respiratory ; stage ; subunit ; syndrome ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.