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Reviewed August 2013
What is the official name of the PIGO gene?
The official name of this gene is “phosphatidylinositol glycan anchor biosynthesis, class O.”
PIGO is the gene's official symbol. The PIGO gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PIGO gene?
The PIGO gene provides instructions for making one part of an enzyme called GPI ethanolamine phosphate transfer 3 (GPI-ET3). The other part of the GPI-ET3 enzyme is produced from a gene called PIGF. The GPI-ET3 enzyme is involved in a series of steps that produce a molecule called a glycosylphosphosphatidylinositol (GPI) anchor. Specifically, this enzyme adds a molecule of ethanolamine phosphate to the end of the forming GPI anchor. This step takes place in the endoplasmic reticulum, which is a structure involved in protein processing and transport within cells. The complete GPI anchor attaches (binds) to various proteins in the endoplasmic reticulum; this process requires the ethanolamine phosphate at the end of the anchor. After the anchor and protein are bound, the anchor attaches itself to the outer surface of the cell membrane, ensuring that the protein will be available when it is needed.
Does the PIGO gene share characteristics with other genes?
The PIGO gene belongs to a family of genes called PIG (phosphatidylinositol glycan anchor biosynthesis).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the PIGO gene related to health conditions?
Where is the PIGO gene located?
Cytogenetic Location: 9p13.3
Molecular Location on chromosome 9: base pairs 35,088,687 to 35,096,600
The PIGO gene is located on the short (p) arm of chromosome 9 at position 13.3.
More precisely, the PIGO gene is located from base pair 35,088,687 to base pair 35,096,600 on chromosome 9.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PIGO?
You and your healthcare professional may find the following resources about PIGO helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PIGO gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PIGO?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.