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Reviewed August 2013
What is the official name of the PGAP2 gene?
The official name of this gene is “post-GPI attachment to proteins 2.”
PGAP2 is the gene's official symbol. The PGAP2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PGAP2 gene?
The PGAP2 gene provides instructions for making a protein that modifies a molecule called a glycosylphosphosphatidylinositol (GPI) anchor. The GPI anchor attaches (binds) to various proteins and then binds them to the outer surface of the cell membrane, ensuring that they are available when needed. The GPI anchor is made up of many different pieces and is assembled in a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport. The anchor is then transferred to a different cell structure called the Golgi apparatus, which modifies newly produced enzymes and other proteins. In the Golgi apparatus, the PGAP2 protein assists in attaching a molecule called a saturated fatty acid to the anchor. This saturated fatty acid is likely needed to help transport and attach the anchor to the fat-rich cell membrane.
How are changes in the PGAP2 gene related to health conditions?
Where is the PGAP2 gene located?
Cytogenetic Location: 11p15.5
Molecular Location on chromosome 11: base pairs 3,818,953 to 3,847,600
The PGAP2 gene is located on the short (p) arm of chromosome 11 at position 15.5.
More precisely, the PGAP2 gene is located from base pair 3,818,953 to base pair 3,847,600 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PGAP2?
You and your healthcare professional may find the following resources about PGAP2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PGAP2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PGAP2?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.