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Reviewed January 2011
What is the official name of the PCNT gene?
The official name of this gene is “pericentrin.”
PCNT is the gene's official symbol. The PCNT gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the PCNT gene?
The PCNT gene provides instructions for making a protein called pericentrin. Within cells, this protein is located in structures called centrosomes. Centrosomes play a role in cell division and the assembly of microtubules. Microtubules are fibers that help cells maintain their shape, assist in the process of cell division, and are essential for the transport of materials within cells.
Pericentrin acts as an anchoring protein, securing proteins to the centrosome that are necessary for its function. Through its interactions with these proteins, pericentrin is involved in the regulation of the cell cycle, which is the cell's way of replicating itself in an organized, step-by-step fashion.
How are changes in the PCNT gene related to health conditions?
Genetics Home Reference provides information about prostate cancer, which is also associated with changes in the PCNT gene.
Where is the PCNT gene located?
Cytogenetic Location: 21q22.3
Molecular Location on chromosome 21: base pairs 46,324,100 to 46,445,769
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The PCNT gene is located on the long (q) arm of chromosome 21 at position 22.3.
More precisely, the PCNT gene is located from base pair 46,324,100 to base pair 46,445,769 on chromosome 21.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about PCNT?
You and your healthcare professional may find the following resources about PCNT helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the PCNT gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding PCNT?
bipolar disorder ; cancer ; cell ; cell cycle ; cell division ; centrosome ; depression ; dwarfism ; gene ; inherited ; leukemia ; lymphoma ; microcephalic ; microcephaly ; prostate ; protein ; schizophrenia ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.