Reviewed December 2011
What is the official name of the OXCT1 gene?
The official name of this gene is “3-oxoacid CoA-transferase 1.”
OXCT1 is the gene's official symbol. The OXCT1 gene is also known by other names, listed below.
What is the normal function of the OXCT1 gene?
The OXCT1 gene provides instruction for making an enzyme called succinyl-CoA:3-ketoacid CoA transferase, often abbreviated as SCOT. The SCOT enzyme is made in the energy-producing centers of cells (mitochondria). The enzyme plays a role in the breakdown of ketones, which are molecules produced by the liver during the breakdown of fats. Ketones are an important source of energy during prolonged periods without food (fasting) or when energy demands are increased, such as during illness or when exercising. In the processing of ketones, the SCOT enzyme converts the molecule acetoacetate to acetoacetyl-CoA.
How are changes in the OXCT1 gene related to health conditions?
- succinyl-CoA:3-ketoacid CoA transferase deficiency - caused by mutations in the OXCT1 gene
At least 20 mutations in the OXCT1 gene have been found to cause SCOT deficiency, a condition characterized by episodes of extreme tiredness, appetite loss, and seizures, known as ketoacidotic attacks. Most OXCT1 gene mutations lead to changes in single protein building blocks (amino acids) in the SCOT enzyme and result in an enzyme with little or no function. A reduction in the amount of functional enzyme leads to an inability to break down ketones, often resulting in decreased energy production and an elevated level of ketones in the blood. If these signs become severe, a ketoacidotic attack can occur.
Where is the OXCT1 gene located?
Cytogenetic Location: 5p13.1
Molecular Location on chromosome 5: base pairs 41,730,065 to 41,870,689
(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBI (http://www.ncbi.nlm.nih.gov/gene/5019))
The OXCT1 gene is located on the short (p) arm of chromosome 5 at position 13.1.
More precisely, the OXCT1 gene is located from base pair 41,730,065 to base pair 41,870,689 on chromosome 5.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
Where can I find additional information about OXCT1?
You and your healthcare professional may find the following resources about OXCT1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
- PubMed - Recent literature (http://www.ncbi.nlm.nih.gov/pubmed?term=%28OXCT1%5BTIAB%5D%29%20OR%20%28%28OXCT%5BTIAB%5D%29%20OR%20%28SCOT%5BTIAB%5D%29%29%20AND%20%28%28Genes%5BMH%5D%29%20OR%20%28Genetic%20Phenomena%5BMH%5D%29%29%20AND%20english%5Bla%5D%20AND%20human%5Bmh%5D%20AND%20%22last%203600%20days%22%5Bdp%5D)
- OMIM - Genetic disorder catalog (http://omim.org/entry/601424)
Research Resources - Tools for researchers
- Atlas of Genetics and Cytogenetics in Oncology and Haematology (http://atlasgeneticsoncology.org/Genes/GC_OXCT1.html)
- HGNC Gene Symbol Report (http://www.genenames.org/cgi-bin/gene_symbol_report?q=data/hgnc_data.php&hgnc_id=8527)
- NCBI Gene (http://www.ncbi.nlm.nih.gov/gene/5019)
What other names do people use for the OXCT1 gene or gene products?
- 3-oxoacid-CoA transferase 1
- 3-oxoacid CoA transferase 1
- somatic-type succinyl CoA:3-oxoacid CoA-transferase
- somatic-type succinyl-CoA:3-oxoacid-CoA-transferase
- succinyl-CoA:3-ketoacid-CoA transferase
- succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial
- succinyl CoA:3-oxoacid CoA transferase
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
What glossary definitions help with understanding OXCT1?
coenzyme A ;
You may find definitions for these and many other terms in the Genetics Home Reference
- OMIM: 3-OXOACID CoA TRANSFERASE 1 (http://omim.org/entry/601424)
- Berry GT, Fukao T, Mitchell GA, Mazur A, Ciafre M, Gibson J, Kondo N, Palmieri MJ. Neonatal hypoglycaemia in severe succinyl-CoA: 3-oxoacid CoA-transferase deficiency. J Inherit Metab Dis. 2001 Oct;24(5):587-95. (http://www.ncbi.nlm.nih.gov/pubmed/11757586?dopt=Abstract)
- Fukao T, Ishii T, Amano N, Kursula P, Takayanagi M, Murase K, Sakaguchi N, Kondo N, Hasegawa T. A neonatal-onset succinyl-CoA:3-ketoacid CoA transferase (SCOT)-deficient patient with T435N and c.658-666dupAACGTGATT p.N220_I222dup mutations in the OXCT1 gene. J Inherit Metab Dis. 2010 Dec;33 Suppl 3:S307-13. doi: 10.1007/s10545-010-9168-5. Epub 2010 Jul 21. (http://www.ncbi.nlm.nih.gov/pubmed/20652411?dopt=Abstract)
- Fukao T, Mitchell GA, Song XQ, Nakamura H, Kassovska-Bratinova S, Orii KE, Wraith JE, Besley G, Wanders RJ, Niezen-Koning KE, Berry GT, Palmieri M, Kondo N. Succinyl-CoA:3-ketoacid CoA transferase (SCOT): cloning of the human SCOT gene, tertiary structural modeling of the human SCOT monomer, and characterization of three pathogenic mutations. Genomics. 2000 Sep 1;68(2):144-51. (http://www.ncbi.nlm.nih.gov/pubmed/10964512?dopt=Abstract)
- Fukao T, Sass JO, Kursula P, Thimm E, Wendel U, Ficicioglu C, Monastiri K, Guffon N, Barić I, Zabot MT, Kondo N. Clinical and molecular characterization of five patients with succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency. Biochim Biophys Acta. 2011 May;1812(5):619-24. doi: 10.1016/j.bbadis.2011.01.015. Epub 2011 Feb 2. (http://www.ncbi.nlm.nih.gov/pubmed/21296660?dopt=Abstract)
- Fukao T, Shintaku H, Kusubae R, Zhang GX, Nakamura K, Kondo M, Kondo N. Patients homozygous for the T435N mutation of succinyl-CoA:3-ketoacid CoA Transferase (SCOT) do not show permanent ketosis. Pediatr Res. 2004 Dec;56(6):858-63. Epub 2004 Oct 20. (http://www.ncbi.nlm.nih.gov/pubmed/15496607?dopt=Abstract)
- NCBI Gene (http://www.ncbi.nlm.nih.gov/gene/5019)
The resources on this site should not be used as a substitute for
professional medical care or advice. Users seeking information about
a personal genetic disease, syndrome, or condition should consult with a qualified
See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.