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Reviewed February 2014
What is the official name of the ORC1 gene?
The official name of this gene is “origin recognition complex subunit 1.”
ORC1 is the gene's official symbol. The ORC1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the ORC1 gene?
The ORC1 gene provides instructions for making a protein that is important in the copying of a cell's DNA before the cell divides (a process known as DNA replication). The protein produced from this gene is one of a group of proteins known as the origin recognition complex (ORC). (The complex is made up of the proteins ORC1 to ORC6, which are produced from different genes.) ORC attaches (binds) to certain regions of DNA known as origins of replication (or origins), where the process of DNA copying begins. This complex attracts additional proteins to bind to it, forming a larger group of proteins called the pre-replication complex. When the pre-replication complex is attached to the origin, replication is able to begin at that location. This tightly controlled process, called replication licensing, helps ensure that DNA replication occurs only once per cell division and is required for cells to divide.
ORC also attaches to a form of DNA called heterochromatin. Heterochromatin is densely packed DNA that contains few functional genes, but it is important for controlling gene activity and maintaining the structure of chromosomes. It is unclear what effect ORC binding has on heterochromatin.
In addition to its roles as part of ORC, the ORC1 protein is involved in the copying of cell structures called centrosomes and centrioles, which are important for the process of cell division. ORC1 blocks centrosomes and centrioles from being copied more than once, which is key to normal cell division. In addition, some research suggests that ORC1 is involved in the function of cilia, which are microscopic, finger-like projections that stick out from the surface of cells. Cilia participate in signaling pathways that transmit information within and between cells and are important for the development and function of many types of cells and tissues, including bone.
Does the ORC1 gene share characteristics with other genes?
The ORC1 gene belongs to a family of genes called ATP (ATPases).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the ORC1 gene related to health conditions?
Where is the ORC1 gene located?
Cytogenetic Location: 1p32
Molecular Location on chromosome 1: base pairs 52,372,829 to 52,404,471
The ORC1 gene is located on the short (p) arm of chromosome 1 at position 32.
More precisely, the ORC1 gene is located from base pair 52,372,829 to base pair 52,404,471 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about ORC1?
You and your healthcare professional may find the following resources about ORC1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the ORC1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding ORC1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (10 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.