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The official name of this gene is “nuclear mitotic apparatus protein 1.”
NUMA1 is the gene's official symbol. The NUMA1 gene is also known by other names, listed below.
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.
|164009 (http://omim.org/entry/164009)||NUCLEAR MITOTIC APPARATUS PROTEIN 1|
Cytogenetic Location: 11q13
Molecular Location on chromosome 11: base pairs 72,002,863 to 72,080,692
The NUMA1 gene is located on the long (q) arm of chromosome 11 at position 13.
More precisely, the NUMA1 gene is located from base pair 72,002,863 to base pair 72,080,692 on chromosome 11.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
acute ; alternative splicing ; axis ; cell ; cell division ; chromosome ; gene ; leukemia ; protein ; receptor ; splicing ; transcript ; translocation
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).
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