Skip Navigation
Genetics Home Reference: your guide to understanding genetic conditions     A service of the U.S. National Library of Medicine®


The information on this page was automatically extracted from online scientific databases.

What is the official name of the NR4A2 gene?

The official name of this gene is “nuclear receptor subfamily 4 group A member 2.”

NR4A2 is the gene's official symbol. The NR4A2 gene is also known by other names, listed below.

What is the normal function of the NR4A2 gene?

From NCBI Gene (

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

From UniProt (NR4A2_HUMAN) (

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.

How are changes in the NR4A2 gene related to health conditions?

NCBI Gene ( lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the NR4A2 gene.
  • Parkinson disease, late-onset (, a catalog designed for genetics professionals and researchers, provides the following information about the NR4A2 gene and its association with health conditions.

Where is the NR4A2 gene located?

Cytogenetic Location: 2q22-q23

Molecular Location on chromosome 2: base pairs 156,324,432 to 156,334,683

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBI (

The NR4A2 gene is located on the long (q) arm of chromosome 2 between positions 22 and 23.

The NR4A2 gene is located on the long (q) arm of chromosome 2 between positions 22 and 23.

More precisely, the NR4A2 gene is located from base pair 156,324,432 to base pair 156,334,683 on chromosome 2.

See How do geneticists indicate the location of a gene? ( in the Handbook.

Where can I find additional information about NR4A2?

You and your healthcare professional may find the following resources about NR4A2 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the NR4A2 gene or gene products?

  • HZF-3
  • NOT
  • NURR1
  • RNR1

See How are genetic conditions and genes named? ( in the Handbook.

What glossary definitions help with understanding NR4A2?

arthritis ; depression ; differentiation ; gene ; hormone ; manic depression ; protein ; receptor ; retinoid ; thyroid ; transcript ; transcription ; transcription factor

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? ( in the Handbook.

Published: February 1, 2016