|http://ghr.nlm.nih.gov/ A service of the U.S. National Library of Medicine®|
The official name of this gene is “nuclear receptor subfamily 4, group A, member 2.”
NR4A2 is the gene's official symbol. The NR4A2 gene is also known by other names, listed below.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.
|168600 (http://omim.org/entry/168600)||PARKINSON DISEASE, LATE-ONSET|
|601828 (http://omim.org/entry/601828)||NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 2|
Cytogenetic Location: 2q22-q23
Molecular Location on chromosome 2: base pairs 156,324,431 to 156,334,682
The NR4A2 gene is located on the long (q) arm of chromosome 2 between positions 22 and 23.
More precisely, the NR4A2 gene is located from base pair 156,324,431 to base pair 156,334,682 on chromosome 2.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You and your healthcare professional may find the following resources about NR4A2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
arthritis ; depression ; differentiation ; gene ; hormone ; manic depression ; protein ; receptor ; retinoid ; thyroid ; transcript ; transcription ; transcription factor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.