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Reviewed January 2014
What is the official name of the NPM1 gene?
The official name of this gene is “nucleophosmin (nucleolar phosphoprotein B23, numatrin).”
NPM1 is the gene's official symbol. The NPM1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the NPM1 gene?
The NPM1 gene provides instructions for making a protein called nucleophosmin, which is found in a small region inside the nucleus of the cell called the nucleolus. Nucleophosmin shuttles back and forth between the nucleus and the fluid surrounding it (the cytoplasm). It is thought to play a part in many cellular functions, including processes involved in protein formation, DNA replication, and the progression of the cell through the step-by-step process it takes to replicate itself (called the cell cycle). In the nucleolus, nucleophosmin attaches to another protein called ARF, keeping it in the proper location and protecting it from being broken down. The ARF protein is considered a tumor suppressor because it is involved in pathways that prevent cells from growing and dividing in an uncontrolled way.
How are changes in the NPM1 gene related to health conditions?
Genetics Home Reference provides information about acute promyelocytic leukemia, which is also associated with changes in the NPM1 gene.
Where is the NPM1 gene located?
Cytogenetic Location: 5q35.1
Molecular Location on chromosome 5: base pairs 171,387,648 to 171,410,884
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The NPM1 gene is located on the long (q) arm of chromosome 5 at position 35.1.
More precisely, the NPM1 gene is located from base pair 171,387,648 to base pair 171,410,884 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about NPM1?
You and your healthcare professional may find the following resources about NPM1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the NPM1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding NPM1?
acids ; acute ; acute myeloid leukemia ; amino acid ; AML ; cancer ; cell ; cell cycle ; cell proliferation ; chromosome ; cytoplasm ; differentiation ; DNA ; DNA replication ; exon ; fusion gene ; gene ; inherited ; leukemia ; lymph ; lymphoma ; mutation ; myeloid ; nucleolus ; nucleus ; phosphoprotein ; progression ; proliferation ; protein ; rearrangement ; somatic mutation ; translocation ; tryptophan ; tumor ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.