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NOS3

NOS3

The information on this page was automatically extracted from online scientific databases.

What is the official name of the NOS3 gene?

The official name of this gene is “nitric oxide synthase 3 (endothelial cell).”

NOS3 is the gene's official symbol. The NOS3 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the NOS3 gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.

How are changes in the NOS3 gene related to health conditions?

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the NOS3 gene.
  • Alzheimer's disease[1]This link leads to a site outside Genetics Home Reference.
  • Essential hypertension[2]This link leads to a site outside Genetics Home Reference.
  • Ischemic stroke[3]This link leads to a site outside Genetics Home Reference.
  • Preeclampsia/eclampsia 1[4]This link leads to a site outside Genetics Home Reference.
UniProt and NCBI Gene cite these articles in OMIM, a catalog designed for genetics professionals and researchers that provides detailed information about genetic conditions and genes.
 Article
Number
Main Topic
[1]
[2]
[3]
[4]

Where is the NOS3 gene located?

Cytogenetic Location: 7q36

Molecular Location on chromosome 7: base pairs 150,991,055 to 151,014,943

The NOS3 gene is located on the long (q) arm of chromosome 7 at position 36.

The NOS3 gene is located on the long (q) arm of chromosome 7 at position 36.

More precisely, the NOS3 gene is located from base pair 150,991,055 to base pair 151,014,943 on chromosome 7.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about NOS3?

You and your healthcare professional may find the following resources about NOS3 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the NOS3 gene or gene products?

  • ECNOS
  • eNOS

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding NOS3?

angiogenesis ; antimicrobial ; arginine ; blood clotting ; clotting ; coronary ; gene ; growth factor ; hypertension ; isoforms ; L-arginine ; platelets ; signal transduction ; susceptibility ; transcript ; transduction ; vascular

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: October 20, 2014