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Reviewed March 2007
What is the official name of the NF2 gene?
The official name of this gene is “neurofibromin 2 (merlin).”
NF2 is the gene's official symbol. The NF2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the NF2 gene?
The NF2 gene provides instructions for the production of a protein called merlin, also known as schwannomin. This protein is made in the nervous system, particularly in specialized cells that wrap around and insulate nerves (Schwann cells).
Merlin is believed to play a role in controlling cell shape, cell movement, and communication between cells. To carry out these tasks, merlin associates with the internal framework that supports the cell (the cytoskeleton). Merlin also functions as a tumor suppressor protein, which prevents cells from growing and dividing too fast or in an uncontrolled way.
How are changes in the NF2 gene related to health conditions?
Where is the NF2 gene located?
Cytogenetic Location: 22q12.2
Molecular Location on chromosome 22: base pairs 29,603,556 to 29,698,600
The NF2 gene is located on the long (q) arm of chromosome 22 at position 12.2.
More precisely, the NF2 gene is located from base pair 29,603,556 to base pair 29,698,600 on chromosome 22.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about NF2?
You and your healthcare professional may find the following resources about NF2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the NF2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding NF2?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (19 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.