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The official name of this gene is “nexilin (F actin binding protein).”
NEXN is the gene's official symbol. The NEXN gene is also known by other names, listed below.
This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.
The disease is caused by mutations affecting the gene represented in this entry.
|||613122 (http://omim.org/entry/613122)||CARDIOMYOPATHY, DILATED, 1CC|
|||613876 (http://omim.org/entry/613876)||CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 20|
|613121 (http://omim.org/entry/613121)||NEXILIN, RAT, HOMOLOG OF|
Cytogenetic Location: 1p31.1
Molecular Location on chromosome 1: base pairs 78,354,199 to 78,412,008
The NEXN gene is located on the short (p) arm of chromosome 1 at position 31.1.
More precisely, the NEXN gene is located from base pair 78,354,199 to base pair 78,412,008 on chromosome 1.
See How do geneticists indicate the location of a gene? (http://ghr.nlm.nih.gov/handbook/howgeneswork/genelocation) in the Handbook.
You and your healthcare professional may find the following resources about NEXN helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
See How are genetic conditions and genes named? (http://ghr.nlm.nih.gov/handbook/mutationsanddisorders/naming) in the Handbook.
actin ; cardiomyopathy ; cell ; cell adhesion ; cytoskeleton ; dilated ; familial ; gene ; hypertrophic ; protein ; sarcomere ; transcript
You may find definitions for these and many other terms in the Genetics Home Reference Glossary (http://ghr.nlm.nih.gov/glossary).
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? (http://ghr.nlm.nih.gov/handbook/consult/findingprofessional) in the Handbook.