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NEXN

NEXN

The information on this page was automatically extracted from online scientific databases.

What is the official name of the NEXN gene?

The official name of this gene is “nexilin (F actin binding protein).”

NEXN is the gene's official symbol. The NEXN gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the NEXN gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity.

How are changes in the NEXN gene related to health conditions?

Genetics Home Reference provides information about familial hypertrophic cardiomyopathy, which is associated with changes in the NEXN gene.
UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the NEXN gene's known or predicted involvement in human disease.

Cardiomyopathy, dilated 1CC (CMD1CC): A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. The disease is caused by mutations affecting the gene represented in this entry.

Cardiomyopathy, familial hypertrophic 20 (CMH20): A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. The disease is caused by mutations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the NEXN gene.
  • Dilated cardiomyopathy 1CC
  • Familial hypertrophic cardiomyopathy 20
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the NEXN gene and its association with health conditions.
OMIM
Number
Title

Where is the NEXN gene located?

Cytogenetic Location: 1p31.1

Molecular Location on chromosome 1: base pairs 77,888,514 to 77,948,642

The NEXN gene is located on the short (p) arm of chromosome 1 at position 31.1.

The NEXN gene is located on the short (p) arm of chromosome 1 at position 31.1.

More precisely, the NEXN gene is located from base pair 77,888,514 to base pair 77,948,642 on chromosome 1.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about NEXN?

You and your healthcare professional may find the following resources about NEXN helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the NEXN gene or gene products?

  • CMH20
  • NELIN

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding NEXN?

actin ; arrhythmia ; benign ; cardiac ; cardiomyopathy ; cell ; cell adhesion ; cytoskeleton ; dilated ; dilation ; dyspnea ; familial ; gene ; heart failure ; hereditary ; hypertrophic ; hypertrophy ; intrafamilial variability ; palpitations ; protein ; sarcomere ; septum ; syncope ; transcript

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: July 27, 2015