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Reviewed January 2010
What is the official name of the NDRG1 gene?
The official name of this gene is “N-myc downstream regulated 1.”
NDRG1 is the gene's official symbol. The NDRG1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the NDRG1 gene?
The NDRG1 gene provides instructions for making a protein whose function is not well understood. The NDRG1 protein may play a role in stopping cell growth and prompting cells to mature and take on specialized functions (differentiate). It probably performs these roles by transmitting signals between the nucleus and other parts of the cell. The NDRG1 protein also interacts with other proteins that help regulate the distribution of fats (lipids) in the body.
The NDRG1 gene is active in cells throughout the body, but its activity is particularly high in specialized cells called Schwann cells. Schwann cells nourish and protect nerve cells, especially the cell extensions (axons) that transmit nerve impulses. Schwann cells also produce myelin, a fatty substance that covers axons and promotes the efficient transmission of nerve impulses. Scientists speculate that the NDRG1 protein is involved in Schwann cell differentiation, myelin maintenance, and the signaling necessary for the survival of nerve axons.
How are changes in the NDRG1 gene related to health conditions?
Where is the NDRG1 gene located?
Cytogenetic Location: 8q24.3
Molecular Location on chromosome 8: base pairs 133,237,170 to 133,297,586
The NDRG1 gene is located on the long (q) arm of chromosome 8 at position 24.3.
More precisely, the NDRG1 gene is located from base pair 133,237,170 to base pair 133,297,586 on chromosome 8.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about NDRG1?
You and your healthcare professional may find the following resources about NDRG1 helpful.
What other names do people use for the NDRG1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding NDRG1?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.