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Reviewed August 2012
What is the official name of the NCF1 gene?
The official name of this gene is “neutrophil cytosolic factor 1.”
NCF1 is the gene's official symbol. The NCF1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the NCF1 gene?
The NCF1 gene provides instructions for making a protein called neutrophil cytosolic factor 1 (also known as p47-phox). This protein is one part (subunit) of a group of proteins that forms an enzyme complex called NADPH oxidase, which plays an essential role in the immune system. NADPH oxidase is primarily active in immune system cells called phagocytes. These cells catch and destroy foreign invaders such as bacteria and fungi. NADPH oxidase is also thought to regulate the activity of immune cells called neutrophils. These cells play a role in adjusting the inflammatory response to optimize healing and reduce injury to the body.
The presence of foreign invaders stimulates phagocytes and triggers the assembly of NADPH oxidase. This enzyme participates in a chemical reaction that converts oxygen to a toxic molecule called superoxide. Superoxide is used to generate several other compounds, including hydrogen peroxide (a strong disinfectant) and hypochlorous acid (the active ingredient in bleach). These highly reactive, toxic substances are known as reactive oxygen species. Phagocytes use these substances to kill foreign invaders, preventing them from reproducing in the body and causing illness.
How are changes in the NCF1 gene related to health conditions?
Where is the NCF1 gene located?
Cytogenetic Location: 7q11.23
Molecular Location on chromosome 7: base pairs 74,773,962 to 74,789,376
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The NCF1 gene is located on the long (q) arm of chromosome 7 at position 11.23.
More precisely, the NCF1 gene is located from base pair 74,773,962 to base pair 74,789,376 on chromosome 7.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about NCF1?
You and your healthcare professional may find the following resources about NCF1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the NCF1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding NCF1?
bacteria ; cell ; chromosome ; chronic ; deletion ; DNA ; enzyme ; exon ; gene ; granulomatous ; hydrogen peroxide ; hypertension ; hypochlorous acid ; immune system ; infection ; inflammation ; injury ; innate immunity ; molecule ; mutation ; neutrophils ; oxidase ; oxygen ; phagocytes ; protein ; reactive oxygen species ; respiratory ; subunit ; syndrome ; toxic
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (12 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.