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Reviewed February 2009
What is the official name of the MYOC gene?
The official name of this gene is “myocilin, trabecular meshwork inducible glucocorticoid response.”
MYOC is the gene's official symbol. The MYOC gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MYOC gene?
The MYOC gene provides instructions for producing a protein called myocilin. Myocilin is found in certain structures of the eye, called the trabecular meshwork and the ciliary body, that regulate the pressure within the eye (intraocular pressure). It is also found in various types of muscle. Myocilin's function is not well understood, but it may help to control the intraocular pressure through its action in the muscle tissue of the ciliary body.
Researchers believe that myocilin functions together with other proteins as part of a protein complex. Myocilin may interact with a number of other proteins including a form of the cytochrome P450 protein, the product of the CYP1B1 gene. Like myocilin, this protein is found in the trabecular meshwork, ciliary body, and other structures of the eye.
How are changes in the MYOC gene related to health conditions?
Where is the MYOC gene located?
Cytogenetic Location: 1q23-q24
Molecular Location on chromosome 1: base pairs 171,604,556 to 171,621,772
The MYOC gene is located on the long (q) arm of chromosome 1 between positions 23 and 24.
More precisely, the MYOC gene is located from base pair 171,604,556 to base pair 171,621,772 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MYOC?
You and your healthcare professional may find the following resources about MYOC helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MYOC gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MYOC?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (15 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.