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Reviewed February 2007
What is the official name of the MYO7A gene?
The official name of this gene is “myosin VIIA.”
MYO7A is the gene's official symbol. The MYO7A gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MYO7A gene?
The MYO7A gene provides instructions for making a protein called myosin VIIA, which is part of a group of proteins called unconventional myosins. These proteins, which have similar structures, each play a role in transporting molecules within cells. Myosins interact with actin, a protein that is important for cell movement and shape. Researchers believe that myosins use long filaments of actin as tracks along which to transport other molecules.
Myosin VIIA is made primarily in the inner ear and the light-sensitive tissue at the back of the eye (the retina). In the inner ear, myosin VIIA plays a role in the development and maintenance of hairlike projections called stereocilia. Stereocilia, which are rich in actin, line the inner ear and bend in response to sound waves. This bending motion is critical for converting sound waves to nerve impulses.
Myosin VIIA is also found in the pigmented cells of the retina (the retinal pigment epithelium or RPE), and probably plays a similar role in the development and maintenance of this tissue. Research suggests that one function of myosin VIIA is to carry small sacs of pigment called melanosomes within the retinal pigment epithelium.
Does the MYO7A gene share characteristics with other genes?
The MYO7A gene belongs to a family of genes called myosins (myosins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the MYO7A gene related to health conditions?
Where is the MYO7A gene located?
Cytogenetic Location: 11q13.5
Molecular Location on chromosome 11: base pairs 77,128,214 to 77,215,241
The MYO7A gene is located on the long (q) arm of chromosome 11 at position 13.5.
More precisely, the MYO7A gene is located from base pair 77,128,214 to base pair 77,215,241 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MYO7A?
You and your healthcare professional may find the following resources about MYO7A helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MYO7A gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MYO7A?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (21 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.