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Reviewed March 2011
What is the official name of the MYCN gene?
The official name of this gene is “v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog.”
MYCN is the gene's official symbol. The MYCN gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MYCN gene?
The MYCN gene provides instructions for making a protein that plays an important role in the formation of tissues and organs during embryonic development. Studies in animals suggest that this protein is necessary for normal development of the limbs, heart, kidneys, nervous system, digestive system, and lungs. The MYCN protein regulates the activity of other genes by attaching (binding) to specific regions of DNA. On the basis of this action, this protein is called a transcription factor.
The MYCN gene belongs to a class of genes known as oncogenes. When mutated, oncogenes have the potential to cause normal cells to become cancerous. The MYCN gene is a member of the Myc family of oncogenes. These genes play important roles in regulating cell growth and division (proliferation) and the self-destruction of cells (apoptosis).
Does the MYCN gene share characteristics with other genes?
The MYCN gene belongs to a family of genes called bHLH (basic helix-loop-helix).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the MYCN gene related to health conditions?
Where is the MYCN gene located?
Cytogenetic Location: 2p24.3
Molecular Location on chromosome 2: base pairs 15,940,560 to 15,947,006
The MYCN gene is located on the short (p) arm of chromosome 2 at position 24.3.
More precisely, the MYCN gene is located from base pair 15,940,560 to base pair 15,947,006 on chromosome 2.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MYCN?
You and your healthcare professional may find the following resources about MYCN helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MYCN gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MYCN?
apoptosis ; cell ; cell division ; class ; digestive ; digestive system ; DNA ; embryonic ; gene ; gene amplification ; inherited ; nervous system ; oncogene ; proliferation ; protein ; proto-oncogene ; syndrome ; transcription ; transcription factor ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (11 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.