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Reviewed July 2011
What is the official name of the MTRR gene?
The official name of this gene is “5-methyltetrahydrofolate-homocysteine methyltransferase reductase.”
MTRR is the gene's official symbol. The MTRR gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MTRR gene?
The MTRR gene provides instructions for making an enzyme called methionine synthase reductase. This enzyme is required for the proper function of another enzyme called methionine synthase. Methionine synthase helps process amino acids, which are the building blocks of proteins. Specifically, it converts the amino acid homocysteine to another amino acid called methionine. After a period of being turned on (active), methionine synthase turns off (becomes inactive). Methionine synthase reductase reactivates methionine synthase so the enzyme can continue to produce methionine.
How are changes in the MTRR gene related to health conditions?
Where is the MTRR gene located?
Cytogenetic Location: 5p15.31
Molecular Location on chromosome 5: base pairs 7,851,185 to 7,901,123
The MTRR gene is located on the short (p) arm of chromosome 5 at position 15.31.
More precisely, the MTRR gene is located from base pair 7,851,185 to base pair 7,901,123 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MTRR?
You and your healthcare professional may find the following resources about MTRR helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MTRR gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MTRR?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (8 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.