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Reviewed July 2011
What is the official name of the MTR gene?
The official name of this gene is “5-methyltetrahydrofolate-homocysteine methyltransferase.”
MTR is the gene's official symbol. The MTR gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MTR gene?
The MTR gene provides instructions for making an enzyme called methionine synthase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Specifically, methionine synthase carries out a chemical reaction that converts the amino acid homocysteine to another amino acid called methionine. The body uses methionine to make proteins and other important compounds. To function properly, methionine synthase requires methylcobalamin (a form of vitamin B12) and another enzyme called methionine synthase reductase, which is produced from the MTRR gene.
How are changes in the MTR gene related to health conditions?
Where is the MTR gene located?
Cytogenetic Location: 1q43
Molecular Location on chromosome 1: base pairs 236,794,304 to 236,903,981
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The MTR gene is located on the long (q) arm of chromosome 1 at position 43.
More precisely, the MTR gene is located from base pair 236,794,304 to base pair 236,903,981 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MTR?
You and your healthcare professional may find the following resources about MTR helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MTR gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MTR?
acids ; adenine ; amino acid ; anemia ; cobalamin ; deficiency ; disability ; DNA ; enzyme ; gene ; guanine ; leucine ; megaloblastic anemia ; methionine ; methyl ; methyltransferase ; neural tube defects ; nucleotide ; proline ; syndrome ; vitamin B12
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.