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Reviewed March 2008
What is the official name of the MSX2 gene?
The official name of this gene is “msh homeobox 2.”
MSX2 is the gene's official symbol. The MSX2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MSX2 gene?
The MSX2 gene provides instructions for producing a protein that is necessary for proper development throughout the body. The MSX2 protein is a transcription factor, which means it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. The presence of the MSX2 protein seems to be particularly critical for the complete development of the skull.
Does the MSX2 gene share characteristics with other genes?
The MSX2 gene belongs to a family of genes called homeobox (homeoboxes).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the MSX2 gene related to health conditions?
Where is the MSX2 gene located?
Cytogenetic Location: 5q35.2
Molecular Location on chromosome 5: base pairs 174,724,572 to 174,730,899
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The MSX2 gene is located on the long (q) arm of chromosome 5 at position 35.2.
More precisely, the MSX2 gene is located from base pair 174,724,572 to base pair 174,730,899 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MSX2?
You and your healthcare professional may find the following resources about MSX2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MSX2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MSX2?
amino acid ; bone formation ; cell ; craniosynostosis ; differentiation ; DNA ; gene ; histidine ; homeobox ; mutation ; ossification ; proliferation ; proline ; protein ; transcription ; transcription factor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (5 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.