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Reviewed September 2014
What is the official name of the MPL gene?
The official name of this gene is “MPL proto-oncogene, thrombopoietin receptor.”
MPL is the gene's official symbol. The MPL gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MPL gene?
The MPL gene provides instructions for making the thrombopoietin receptor protein, which promotes the growth and division (proliferation) of cells. This receptor is especially important for the proliferation of certain blood cells called megakaryocytes, which produce platelets, the cells involved in blood clotting. Research suggests that the thrombopoietin receptor may also play a role in the maintenance of hematopoietic stem cells, which are stem cells located within the bone marrow that have the potential to develop into red blood cells, white blood cells, and platelets.
The thrombopoietin receptor is turned on (activated) when a protein called thrombopoietin attaches (binds) to it. The activated thrombopoietin receptor stimulates a signaling pathway called the JAK/STAT pathway, which transmits chemical signals from outside the cell to the cell's nucleus and is important for controlling the production of blood cells.
Does the MPL gene share characteristics with other genes?
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the MPL gene related to health conditions?
Where is the MPL gene located?
Cytogenetic Location: 1p34
Molecular Location on chromosome 1: base pairs 43,337,418 to 43,354,464
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The MPL gene is located on the short (p) arm of chromosome 1 at position 34.
More precisely, the MPL gene is located from base pair 43,337,418 to base pair 43,354,464 on chromosome 1.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MPL?
You and your healthcare professional may find the following resources about MPL helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MPL gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MPL?
amino acid ; asparagine ; blood clotting ; bone marrow ; cell ; clotting ; collagen ; congenital ; familial ; fibrosis ; gene ; hematopoietic ; inherited ; leucine ; leukemia ; mutation ; nucleus ; oncogene ; platelets ; precursor ; proliferation ; protein ; proto-oncogene ; receptor ; serine ; sporadic ; stem cells ; thrombocytopenia ; thrombosis ; tissue ; tryptophan ; virus ; white blood cells
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (7 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.