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Reviewed March 2014
What is the official name of the MOCS2 gene?
The official name of this gene is “molybdenum cofactor synthesis 2.”
MOCS2 is the gene's official symbol. The MOCS2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MOCS2 gene?
The MOCS2 gene provides instructions for making two different proteins, MOCS2A and MOCS2B, which combine to form an enzyme called molybdopterin synthase. Molybdopterin synthase performs the second of a series of reactions in the formation (biosynthesis) of a molecule called molybdenum cofactor. Molybdenum cofactor, which contains the element molybdenum, is essential to the function of several enzymes called sulfite oxidase, aldehyde oxidase, xanthine dehydrogenase, and mitochondrial amidoxime reducing component (mARC). These enzymes help break down (metabolize) different substances in the body, some of which are toxic if not metabolized.
How are changes in the MOCS2 gene related to health conditions?
Where is the MOCS2 gene located?
Cytogenetic Location: 5q11
Molecular Location on chromosome 5: base pairs 53,095,678 to 53,109,771
The MOCS2 gene is located on the long (q) arm of chromosome 5 at position 11.
More precisely, the MOCS2 gene is located from base pair 53,095,678 to base pair 53,109,771 on chromosome 5.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MOCS2?
You and your healthcare professional may find the following resources about MOCS2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MOCS2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MOCS2?
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.