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Reviewed January 2015
What is the official name of the MID1 gene?
The official name of this gene is “midline 1.”
MID1 is the gene's official symbol. The MID1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MID1 gene?
The MID1 gene is part of a group of genes called the tripartite motif (TRIM) family. Proteins produced from this large family of genes are involved in many cellular activities. Primarily, TRIM proteins play a role in the cell machinery that recycles unwanted proteins by tagging them with a protein called ubiquitin. Ubiquitin serves as a signal to move these unwanted proteins into specialized structures known as proteasomes, where the proteins are recycled.
The MID1 gene provides instructions for making a protein called midline-1. This protein attaches (binds) to microtubules, which are rigid, hollow fibers that make up the cell's structural framework (the cytoskeleton). Microtubules help cells maintain their shape, assist in the process of cell division, and are essential for the movement of cells (cell migration). Midline-1 is responsible for recycling certain proteins, including protein phosphatase 2A (PP2A), integrin alpha-4 (ITGA4), and serine/threonine-protein kinase 36 (STK36). The recycling of these three proteins so they can be reused instead of broken down is essential because they are necessary for normal cellular functioning.
Does the MID1 gene share characteristics with other genes?
The MID1 gene belongs to a family of genes called fibronectin type III domain containing (fibronectin type III domain containing). It also belongs to a family of genes called RNF (RING-type zinc fingers). It also belongs to a family of genes called TRIM (tripartite motif-containing).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the MID1 gene related to health conditions?
Where is the MID1 gene located?
Cytogenetic Location: Xp22
Molecular Location on the X chromosome: base pairs 10,445,310 to 11,111,177
(Homo sapiens Annotation Release 107, GRCh38.p2) (
The MID1 gene is located on the short (p) arm of the X chromosome at position 22.
More precisely, the MID1 gene is located from base pair 10,445,310 to base pair 11,111,177 on the X chromosome.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MID1?
You and your healthcare professional may find the following resources about MID1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MID1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MID1?
acids ; amino acid ; BBB ; cell ; cell division ; cytoskeleton ; gene ; hypertelorism ; kinase ; microtubule ; motif ; ocular hypertelorism ; phosphatase ; protein ; serine ; syndrome ; threonine ; ubiquitin
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (13 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.