Skip Navigation
Genetics Home Reference: your guide to understanding genetic conditions About   Site Map   Contact Us
 
Home A service of the U.S. National Library of Medicine®
 
 
Printer-friendly version
MGP

MGP

The information on this page was automatically extracted from online scientific databases.

What is the official name of the MGP gene?

The official name of this gene is “matrix Gla protein.”

MGP is the gene's official symbol. The MGP gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the MGP gene?

From NCBI GeneThis link leads to a site outside Genetics Home Reference.:

The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

From UniProtThis link leads to a site outside Genetics Home Reference.:

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

How are changes in the MGP gene related to health conditions?

UniProtThis link leads to a site outside Genetics Home Reference. provides the following information about the MGP gene's known or predicted involvement in human disease.

Keutel syndrome (KS): Autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. The disease is caused by mutations affecting the gene represented in this entry.

NCBI GeneThis link leads to a site outside Genetics Home Reference. lists the following diseases or traits (phenotypes) known or believed to be associated with changes in the MGP gene.
  • Keutel syndrome
OMIM.orgThis link leads to a site outside Genetics Home Reference., a catalog designed for genetics professionals and researchers, provides the following information about the MGP gene and its association with health conditions.
OMIM
Number
Title

Where is the MGP gene located?

Cytogenetic Location: 12p12.3

Molecular Location on chromosome 12: base pairs 14,881,180 to 14,885,918

The MGP gene is located on the short (p) arm of chromosome 12 at position 12.3.

The MGP gene is located on the short (p) arm of chromosome 12 at position 12.3.

More precisely, the MGP gene is located from base pair 14,881,180 to base pair 14,885,918 on chromosome 12.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about MGP?

You and your healthcare professional may find the following resources about MGP helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the MGP gene or gene products?

  • GIG36
  • MGLAP
  • NTI

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding MGP?

autosomal ; autosomal recessive ; bone formation ; calcification ; cartilage ; gene ; hypoplasia ; isoforms ; peripheral ; protein ; pulmonary ; pulmonary stenosis ; recessive ; stenosis ; syndrome ; transcript

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

 

The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

 
Published: December 22, 2014