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Reviewed August 2013
What is the official name of the MEN1 gene?
The official name of this gene is “multiple endocrine neoplasia I.”
MEN1 is the gene's official symbol. The MEN1 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MEN1 gene?
The MEN1 gene provides instructions for making a protein called menin. This protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. Although the exact function of menin is unclear, it is likely involved in several important cell functions. For example, it may play a role in copying and repairing DNA and regulating the controlled self-destruction of cells (apoptosis). The menin protein is present in the nucleus of many different types of cells and appears to be active in all stages of development.
Menin interacts with many other proteins, including several transcription factors. Transcription factors bind to specific areas of DNA and help control whether particular genes are turned on or off. Some of these genes likely play a role in cell growth and division. Researchers are working to identify the proteins that interact with menin and determine its specific role as a tumor suppressor.
How are changes in the MEN1 gene related to health conditions?
Genetics Home Reference provides information about primary macronodular adrenal hyperplasia, which is also associated with changes in the MEN1 gene.
Where is the MEN1 gene located?
Cytogenetic Location: 11q13
Molecular Location on chromosome 11: base pairs 64,803,514 to 64,811,294
The MEN1 gene is located on the long (q) arm of chromosome 11 at position 13.
More precisely, the MEN1 gene is located from base pair 64,803,514 to base pair 64,811,294 on chromosome 11.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MEN1?
You and your healthcare professional may find the following resources about MEN1 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MEN1 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MEN1?
acids ; amino acid ; apoptosis ; bronchi ; calcium ; cell ; DNA ; familial ; gene ; genome ; hormone ; hypercalcemia ; hyperparathyroidism ; hyperplasia ; hypertension ; inherited ; kidney ; kidney stones ; mutation ; neoplasia ; nucleus ; pancreas ; pancreatic ; parathyroid ; pituitary gland ; protein ; sign ; sporadic ; transcription ; tumor
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (12 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.