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Reviewed May 2010

What is the official name of the MCM6 gene?

The official name of this gene is “minichromosome maintenance complex component 6.”

MCM6 is the gene's official symbol. The MCM6 gene is also known by other names, listed below.

Read more about gene names and symbols on the About page.

What is the normal function of the MCM6 gene?

The MCM6 gene provides instructions for making part of the MCM complex, a group of proteins that functions as a helicase. Helicases attach to particular regions of DNA and temporarily unwind the two spiral strands of these molecules. When a cell prepares to divide to form two cells, helicases unwind the DNA so that it can be copied. The DNA that makes up the chromosomes is duplicated (replicated) so that each new cell will get a complete set of chromosomes. Helicases are also involved in the production of RNA, a chemical cousin of DNA.

How are changes in the MCM6 gene related to health conditions?

lactose intolerance - course of condition modified by variations in the MCM6 gene

A specific DNA sequence within the MCM6 gene called a regulatory element helps control the activity (expression) of a nearby gene called LCT. The LCT gene provides instructions for making an enzyme called lactase. This enzyme helps to digest lactose, a sugar found in milk and other dairy products. Lactose intolerance in adulthood is caused by gradually decreasing expression of the LCT gene after infancy, which occurs in most humans.

At least four variations have been identified in the regulatory element that modulates LCT gene expression. These variations change single DNA building blocks (nucleotides) in the regulatory element. Each of the variations results in sustained lactase production in the small intestine and the ability to digest lactose throughout life. People without these changes have a reduced ability to digest lactose as they get older, resulting in the signs and symptoms of lactose intolerance.

Where is the MCM6 gene located?

Cytogenetic Location: 2q21

Molecular Location on chromosome 2: base pairs 135,839,626 to 135,876,477

(Homo sapiens Annotation Release 107, GRCh38.p2) (NCBIThis link leads to a site outside Genetics Home Reference.)

The MCM6 gene is located on the long (q) arm of chromosome 2 at position 21.

The MCM6 gene is located on the long (q) arm of chromosome 2 at position 21.

More precisely, the MCM6 gene is located from base pair 135,839,626 to base pair 135,876,477 on chromosome 2.

See How do geneticists indicate the location of a gene? in the Handbook.

Where can I find additional information about MCM6?

You and your healthcare professional may find the following resources about MCM6 helpful.

You may also be interested in these resources, which are designed for genetics professionals and researchers.

What other names do people use for the MCM6 gene or gene products?

  • DNA replication licensing factor MCM6
  • MCG40308
  • MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe)
  • minichromosome maintenance deficient 6 homolog
  • minichromosome maintenance deficient (mis5, S. pombe) 6
  • Mis5
  • MIS5 homolog
  • P105MCM

Where can I find general information about genes?

The Handbook provides basic information about genetics in clear language.

These links provide additional genetics resources that may be useful.

What glossary definitions help with understanding MCM6?

cell ; DNA ; DNA replication ; enzyme ; gene ; gene expression ; helicase ; intestine ; RNA

You may find definitions for these and many other terms in the Genetics Home Reference Glossary.

See also Understanding Medical Terminology.

References (9 links)


The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.

Reviewed: May 2010
Published: February 8, 2016