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Reviewed March 2012
What is the official name of the MBL2 gene?
The official name of this gene is “mannose-binding lectin (protein C) 2, soluble.”
MBL2 is the gene's official symbol. The MBL2 gene is also known by other names, listed below.
Read more about gene names and symbols on the About page.
What is the normal function of the MBL2 gene?
The MBL2 gene provides instructions for making a protein that assembles into a protein complex called mannose-binding lectin. Functional mannose-binding lectins are made up of two to six protein groups called trimers, which are each composed of three of the protein pieces (subunits) produced from the MBL2 gene. This protein complex plays an important role in the immune system's response to foreign invaders (pathogens).
Mannose-binding lectin recognizes and attaches (binds) to sugars, such as mannose, fucose, and glucose, that are found on the surface of bacteria, viruses, and yeast. This binding turns on (activates) the complement system, which is a group of immune system proteins that work together to destroy pathogens, trigger inflammation, and remove debris from cells and tissues. Attachment of mannose-binding lectin also targets the pathogen to be engulfed and broken down by special immune cells. Recognition of foreign invaders by mannose-binding lectin provides one of the body's first lines of defense against infection.
Does the MBL2 gene share characteristics with other genes?
The MBL2 gene belongs to a family of genes called COLEC (collectins).
A gene family is a group of genes that share important characteristics. Classifying individual genes into families helps researchers describe how genes are related to each other. For more information, see What are gene families? in the Handbook.
How are changes in the MBL2 gene related to health conditions?
Where is the MBL2 gene located?
Cytogenetic Location: 10q11.2
Molecular Location on chromosome 10: base pairs 52,765,379 to 52,772,840
The MBL2 gene is located on the long (q) arm of chromosome 10 at position 11.2.
More precisely, the MBL2 gene is located from base pair 52,765,379 to base pair 52,772,840 on chromosome 10.
See How do geneticists indicate the location of a gene? in the Handbook.
Where can I find additional information about MBL2?
You and your healthcare professional may find the following resources about MBL2 helpful.
You may also be interested in these resources, which are designed for genetics professionals and researchers.
What other names do people use for the MBL2 gene or gene products?
See How are genetic conditions and genes named? in the Handbook.
Where can I find general information about genes?
The Handbook provides basic information about genetics in clear language.
These links provide additional genetics resources that may be useful.
What glossary definitions help with understanding MBL2?
acids ; amino acid ; bacteria ; deficiency ; DNA ; exon ; fucose ; gene ; glucose ; immune system ; infection ; inflammation ; mannose ; pathogen ; precursor ; promoter ; promoter region ; protein ; soluble ; subunit
You may find definitions for these and many other terms in the Genetics Home Reference Glossary.
See also Understanding Medical Terminology.
References (6 links)
The resources on this site should not be used as a substitute for professional medical care or advice. Users seeking information about a personal genetic disease, syndrome, or condition should consult with a qualified healthcare professional. See How can I find a genetics professional in my area? in the Handbook.